Synthesis and biological evaluation of 4-aroyl-6,7,8-trimethoxyquinolines as a novel class of anticancer agents.

نویسندگان

  • Cheng-Chih Hsieh
  • Hsueh-Yun Lee
  • Chih-Ying Nien
  • Ching-Chuan Kuo
  • Chi-Yen Chang
  • Jang-Yang Chang
  • Jing-Ping Liou
چکیده

A series of 2-aroyl and 2-aryl-5,6,7-trimethoxyquinoline and 4-aroyl-6,7,8-trimethoxyquinoline combretastatin analogs were synthesized and evaluated for their potential anticancer activity. The 4-aroylquinoline 11 inhibited the growth of the human cancer cells lines KB, HT-29, and MKN45, as well as the three human resistant cancer cell lines KB-vin10, KB-S15, and KB-7D, with IC₅₀ values of 217, 327, 239, 246, 213, and 252 nM, respectively.

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عنوان ژورنال:
  • Molecules

دوره 16 3  شماره 

صفحات  -

تاریخ انتشار 2011